Human induced pluripotent stem cells generated from a patient with idiopathic basal ganglia calcification
نویسندگان
چکیده
Idiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disease, characterized by abnormal calcium deposits in of the brain. The affected individuals exhibit movement disorders, and progressive deterioration cognitive psychiatric ability. genetic cause disease mutation one several different genes, SLC20A2, PDGFB, PDGFRB, XPR1 or MYORG, which inheritably sporadically occurs. Here we generated an induced pluripotent stem cell (iPSC) line from IBGC patient, likely be powerful tool for revealing pathomechanisms exploring potential therapeutic candidates IBGC.
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ژورنال
عنوان ژورنال: Stem Cell Research
سال: 2021
ISSN: ['1876-7753', '1873-5061']
DOI: https://doi.org/10.1016/j.scr.2021.102274